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Total 55174 results found since Jan 2013.
Sympathetic nervous system hyperactivity results in potent cerebral hypoperfusion in swine
CONCLUSION: In swine, SCG stimulation resulted in significant cerebral perfusion deficit, and this was inhibited by prior local anesthetic injection into the SCG. Inhibiting sympathetic activation by targeting the SCG may be an effective treatment for sympathetic mediated cerebral hypoperfusion.PMID:35567916 | DOI:10.1016/j.autneu.2022.102987
Source: Autonomic Neuroscience - May 14, 2022 Category: Neuroscience Authors: Wi Jin Kim Michael Dacey Hashitha Milan Samarage David Zarrin Keshav Goel Christopher Chan Xin Qi Anthony C Wang Kalyanam Shivkumar Jeffrey Ardell Geoffrey P Colby Source Type: research
Effects of intravenous, sternal, and humerus intraosseous administration of Hextend on time of administration and hemodynamics in a hypovolemic swine model.
CONCLUSION: When IV access is difficult, both HIO and SIO are effective techniques for rapid vascular access and the administration of Hextend for patients in hypovolemic shock.
PMID: 28134417 [PubMed - in process]
Source: American Journal of Disaster Medicine - February 1, 2017 Category: Global & Universal Tags: Am J Disaster Med Source Type: research
Perturbations in myocardial perfusion and oxygen balance in swine with multiple risk factors: a novel model of ischemia and no obstructive coronary artery disease
In conclusion, common comorbidities in swine result in CMD, in the absence of appreciable atherosclerosis, which is severe en ough to produce perturbations in myocardial oxygen balance, particularly during exercise, resembling key features of INOCA.
Source: Basic Research in Cardiology - February 24, 2020 Category: Cardiology Source Type: research
Effects of tibial intraosseous and intravenous administration of Hextend on time of administration and hemodynamics in a hypovolemic swine model.
CONCLUSION: TIO is an effective and easily used method to administer Hextend for patients in hypovolemic shock. Based upon the findings of this study, the TIO route might be considered the first choice for rapid vascular access and the administration of Hextend.
PMID: 28134418 [PubMed - in process]
Source: American Journal of Disaster Medicine - February 1, 2017 Category: Global & Universal Tags: Am J Disaster Med Source Type: research
P-026 Aqua embolic system: evaluating the performance of a new liquid embolic system using a swine AVM model
ConclusionsAES, which is a DMSO free, non-adhesive polysaccharides based LEM, may be used as an embolic material for the treatment of hemorrhagic stroke caused by cerebrovascular diseases, such as brain AVM.A: common carotid artery injection (AP view) shows left ascending pharyngeal artery (APA) and left rete mirabile (red arrow). B: AES is injected from the microcatheter. The AES reflux is reaching the tip of the microcatheter. C: With continuous injection of AES, the microcotheter tip is embedded ¡n the cost of AES. D. Post treatment angiogram shows complete occlusion of the left rete mirabile and APADisclosures I....
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Yuki, I., Ohkawa, K., Li, S., Steward, E., Nguyen, B., Hsu, F., Xu, J., Suzuki, S. Tags: Oral poster abstracts Source Type: research
Exercise and hypoxia unmask pulmonary vascular disease and right ventricular dysfunction in a 10-12 week old swine model of neonatal oxidative injury
In conclusion, duration of neonatal hypoxia appears an important determinant of alterations in cardiopulmonary function that persist further into life. These changes encompass both the pulmonary vasculature, and the response of the heart to hypoxia and exercise. Abstract figure legend Exposure of Neonatal Swine to hypoxia for up to four weeks resulted in an increase in pulmonary vascular resistance (PVR) and right ventricular hypertrophy that persisted after recovery in normoxia. Exercise experiments revealed an increased dependency on nitric oxide (NO) to maintain a PVR low, as well as a reduced stroke volume (SV) during ...
Source: The Journal of Physiology - July 21, 2022 Category: Physiology Authors: Jarno J Steenhorst Alexander Hirsch Annemarie Verzijl Piotr Wielopolski Daphne de Wijs-Meijler Dirk J Duncker Irwin K M Reiss Daphne Merkus Source Type: research
O-038 Sympathetic nervous system activation causes cerebral perfusion deficit and cerebral vasoconstriction in Swine
ConclusionIn swine, electrical stimulation of SCG results in reproducible cerebral vasoconstriction and perfusion deficit comparable to cerebral vasospasm. This can be inhibited by prior local anesthetic injection into the SCG, a possible therapeutic target for cerebral vasospasm.Abstract O-038 Figure 1CT perfusion scan (top row) coronel view of approximate fronto-temporal area of swine brain (outlined in white box) at baseline, with right SCG stimulation, with lidocainc + right SCG stimulation. Cerebral angiogram (bottom row) AP view of swine cranial artcrics at baseline, with right SCG stimulation, with lidocaine + right...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Kim, W., Samarage, M., Zarrin, D., Goel, K., Johnson, J., Wang, A., Colby, G. Tags: SNIS 19th annual meeting oral abstracts Source Type: research
A comparison of etanercept vs. infliximab for the treatment of post-arrest myocardial dysfunction in a swine model of ventricular fibrillation
Conclusions: Only infliximab demonstrated a beneficial effect on post cardiac arrest hemodynamics and LV function in this swine model. Etanercept was no better in this regard than saline.
Source: Resuscitation - January 11, 2013 Category: Emergency Medicine Authors: Scott T. Youngquist, James T. Niemann, Atman P. Shah, Joseph L. Thomas, John P. Rosborough Tags: Experimental Source Type: research
Ivabradine in acute heart failure: Effects on heart rate and hemodynamic parameters in a randomized and controlled swine trial.
CONCLUSIONS: Ivabradine reduces heart rate and increases stroke volume without modifying systemic or left filling pressures in a swine model of acute heart failure. However, an excessive heart rate reduction could lead to a decrease in cardiac output and an increase in right filling pressures. Future studies with specific heart rate targets are needed.
PMID: 30155868 [PubMed - as supplied by publisher]
Source: Cardiology Journal - August 29, 2018 Category: Cardiology Authors: Pascual Izco M, Ramírez-Carracedo R, Hernández Navarro I, Osorio Ruiz Á, Castejón Navarro B, Cuadrado Berrocal I, Largo Aramburu C, Alonso Salinas GL, Díez J, Saura Redondo M, Zamorano Gómez JL, Zaragoza C, Sanmartín M Tags: Cardiol J Source Type: research
A swine model of intracellular cerebral edema – Cerebral physiology and intracranial compliance
We describe a swine model of water intoxication and its cerebral histological and physiological sequela. We studied female swine weighing 35–45 kg. Four serum sodium intervals were designated: baseline, mild, moderate, and severe hyponatremia attained by infusing hypotonic saline. Intracranial fluid injections were performed to assess intracranial compliance. At baseline and following water intoxication wedge biopsy was obtained for pathological examination and electron microscopy. We studied 8 swine and found an increase in ICP that was strongly related to the decrease in serum sodium level. Mean ICP rose from a basel...
Source: Journal of Clinical Neuroscience - October 26, 2018 Category: Neuroscience Source Type: research
